In Middletown, at 11:14 PM, two cars accidents happen at the same time, affecting the lives of five different groups of people. A drunken driver hits a man in a lonely road near a bridge; three young men hits a woman with a van, one of the passenger  on the road shoots them; a young man robs a convenience store, with the support of the clerk; a man finds a body in a cemetery and gets rid off it; and a young woman pretending to be pregnant tries to raise money for an abortion. All of these characters and their fates are very connected

Mike Enslin (Cusack) is a skeptic and author who debunks supernatural occurrences after the untimely death of his daughter Katie. After his latest successful book, he receives an anonymous postcard of the Dolphin Hotel in New York City bearing the message "don't enter 1408." Viewing this as a challenge, Enslin attempts to book a reservation in room 1408, but the hotel will not rent him the room. However, after being informed by Mike's agent (Shaloub) that the Fair Housing Act requires hotels to rent unoccupied rooms the Dolphin reluctantly reserves room 1408 for Enslin.

Arriving at the Dolphin, Mike is pulled aside by the hotel's manager Gerald Olin (Jackson), who warns him that no one has lasted more than an hour in 1408. Olin offers Enslin an upgrade to the penthouse suite, access to documents regarding the deaths in 1408, and an $800 bottle of cognac. Mike accepts the documents and the cognac but insists on staying in the room, frustrating Olin. The manager gives him the key, warning him that "It's an EVIL  room."

At a remote mansion overlooking a vast, empty bay lake, Countess Federica (Isa Miranda), wheels herself through her dark, empty house. She sorrowfully looks out her window at the rain when Filippo Donati (Giovanni Nuvoletti), her husband, appears and murders her by wrapping a noose around her neck and kicks her out of her wheelchair. The countess cannot stand on or move her useless legs and is strangled to death. But then Filippo is then murdered by a unseen killer who jumps out at him from behind a curtain, and drags his body away. The presence of a suicide note, stolen from the countess' diary, leads the police to believe that she has killed herself.

Several days later, Frank Ventura (Chris Avram), a real estate agent, and his secretary/lover Laura (Anna Maria Rosati) are in bed discussing their plans to take over Countess Federicas property following her murder. They both realized the bay's potential to fetch a large price on the estate market, and they are the ones who have convinced Donati to murder his wife. All that Ventura needs to take control of the bay is Donati's signature on some paperwork, although he does not realize that Donati too has been murdered. Ventura plans to go to his cottage, which adjoins the desired property, to meet with Donati. Laura, jealous of Ventura's obsession with the property, asks to come along. When he tells her to stay put, she complains that he enjoys making her life miserable. Ventura tells Laura about a 'squonk' which is mystical creature who is crafty, but never stops whimpering. Laura understands the analogy and agrees to be patient.

A man living in rural Wisconsin takes care of his bed-ridden mother, who is very domineering and teaches him that all women are evil. After she dies he misses her, so a year later he digs her up and takes her home. He learns about taxidermy and begins robbing graves to get materials to patch her up, and inevitably begins looking for fresher sources of materials. Based closely on the true story of Ed Gein

After a high school senior, Wendy Christensen, has a fatal premonition of a disastrous roller-coaster accident that involves her and her friends, she warns everyone and luckily gets herself and many of her friends and others off the roller-coaster before it sets off, after they get off and the roller-coaster starts off, it crashes just like in her premonition, soon she teams up with a friend, Kevin Fischer as well as many other people, some including Erin and Ian to try and cheat death. Will they succeed or will they learn a lesson that you just can't cheat death? 

The movie begins with the showing of original footage from some of the 311 nuclear tests that were carried out by the U.S. government in the desert of New Mexico during the years 1945-1992. The government had ordered the local residents to move so they wouldn't get hurt by the atomic tests. But some of the residents (miners) refused to leave their homes, and were exposed to dangerous levels of radiation. The miners went to the mines and survived, but their newborn children were genetically altered. The children are now adults, and to survive in the desert, they murder and rob tourists going through the desert. They are not only insane murderers, but they have become blood-thirsty cannibals. The Carter family has an accident in the desert, and they are about to become the next victims. However, Big Bob Carter, (Ted Levine), a retired police detective, isn't going to let that happen. Douglas Young (the-movie-guy)

Jerry, Bill, Mary, and Denise are two couples out on the road in hopes of writing a book on offbeat roadside attractions. When the four meet Captain Spaulding, they learn of the legend of Dr. Satan. When the four take off in search of finding the tree that Dr. Satan was hung from, they pick up hitchhiker Baby. When their car breaks down, Baby invites them into her house. This is where the two couples meet the Firefly family, a murderous clan of bizarre people. As the family attacks the unsuspecting couples, Jerry and his friends try to survive the house of 1000 corpses and it's dark secrets

Three sisters and a group of their friends take a trip to the home of the recently deceased grandfather -- who died a particularly grisly death -- to learn more about the promise of an inheritance, only to encounter a family of psychos who have taken up residence in the old man's cabi

A pair of teenage girls are headed to a rock concert for one's birthday. While trying to score marijuana in the city, the girls are kidnapped by a gang of psychotic convicts.Mari and Phyllis go to the "big city" to see their favorite band BloodLust. Along the way they meet up with newly escaped convict Krug and his gang.After kidnapping and butchering two teenagers, a gang of rapists and murderers unknowingly seeks refuge with the parents of one of the victims

A young couple staying in an isolated vacation home are terrorized by three unknown assailants.After returning from a wedding reception, a couple staying in an isolated vacation house receive a knock on the door in the mid-hours of the night. What ensues is a violent invasion by three strangers, their faces hidden behind masks. The couple find themselves in a violent struggle, in which they go beyond what either of them thought capable in order to survive.